Protein Details: P2X purinoceptor 5

Protein ID

ICDB_Pro_1382

Protein Name

P2X purinoceptor 5

Gene Name

P2RX5; P2X5

Organism

Homo sapiens (Human)

Length

422 amino acids

AlphaFoldDB

AF-Q93086-F1-model_v4.pdb

Function

[Isoform 6]: ATP-gated nonselective transmembrane cation channel permeable to potassium;sodium and calcium. Unlike;other P2RX receptors;the P2X5 receptor is also permeable to chloride. May play a supporting role in the inflammatory response (By similarity).

Sequence

MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHRST

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Canavan Disease

Location

Expressed at high levels in brain and immune system

DOI ID

10.1016/s0014-5793(97)01380-x; 10.1101/gr.10.2.165; 10.1038/ng1285; 10.1038/nature04689; 10.1101/gr.2596504; 10.1124/mol.63.6.1407; 10.1074/jbc.m606113200; 10.1124/mol.110.063636

RefSeq

NP_001191448.1 [Q93086-1]; NP_001191449.1 [Q93086-5]; NP_002552.2 [Q93086-3]; NP_778255.1 [Q93086-2]